Structural biology technologies/software

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Sample preparation for structural and molecular biology studie

Provided by INSTRUCT-ERIC

instruct-eric

Sample preparation is an essential prelude for structural and molecular biology studies, as well as for biotechnology and drug discovery application, which can be particularly challenging in the case of eukaryotic proteins and complexes. Instruct offer state-of-the-art infrastructures for the expression and production of biomolecules and their complexes in prokaryotic and eukaryotic systems .
Sample Preparation: Crystallisation, Nanobody Discovery, Protein Production;
Biomolecular Analysis: Imaging, Mass Spectrometry, Molecular Biophysics;
3D Structural Analysis: Electron Microscopy, Magnetic Resonance Techniques, X-ray Techniques;

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Human Phenotype Ontology

Provided by HPO - THE HUMAN PHENOTYPE ONTOLOGY

Human Phenotype Ontology

HPO provides an ontology of medically relevant phenotypes, disease-phenotype annotations, and the algorithms that operate on these to allow large-scale computational analysis of the human phenome. The HPO can be used to support differential diagnostics, translational research, and a number of applications in computational biology by providing the means to compute over the clinical phenotype. The HPO is being used for computational deep phenotyping and precision medicine as well as integration of clinical data into translational research. Although initially focused on rare, mainly Mendelian diseases, the focus of the HPO will be extended to other areas of medicine in coming years.
Tools:
* Exomiser: evaluate variants based on the predicted pathogenicity
*genomiser: analyze genome sequence data for non-coding variants
* phenomizer: rank disease differential diagnosis by clinical features
*profile search: discover diseases with a phenotype profile

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