Mouse models

Provided by PHENOMIN

Phenomin provides access to more than 50 mouse rare disease models. These models are useful for decrypting the mechanisms behind of the specific disease and form a platform for testing therapies

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 Mouse Models



Services offered by INFRAFRONTIER include
• Rodent Model Generation (generation of custom rodent mutant strains using the latest genome-editing technologies by expert laboratories)
• Cryopreservation (Mutant mouse models generated by researchers around the world are archived using the latest cryopreservation techniques in the European Mouse Mutant Archive (EMMA).
• Strain Distribution (The deposited mutant mouse lines are sent to researchers around the globe as frozen gametes or live cohorts.
• Mouse Phenotyping (These systematic phenotyping platforms incorporate whole-system screen covering different diseases and organ systems.
• Axenic Service (This service offers the germ-free derivation of user-provided mouse strains. These germ-free mice can be used for different gnotobiotic studies that shed light on the important contribution of the gut microbiota to health disease).
• Open Calls (free-of-charge cancer and infectious disease services funded by the European Commission).
• Cancer Services (Via the canSERV project, INFRAFRONTIER offers access to several cutting-edge cancer services as Trans-National Access calls).

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Phenotyping of Laboratory Animals


The SEFALer platform is a pioneering network structure seeking to provide a comprehensive service in all phases of phenotyping animal models of rare diseases. It is structured through cooperation between services provided by CIBERER groups through different institutions.Actvities include:
1. Characterisation of animal models of human rare diseases.
*Secondary functional phenotyping in the following contexts:
– Platforms for phenotyping transgenic mice.
– Pharmacology and toxicology.
– Degeneration and regeneration studies.
– Ageing studies.
– Characterisation of experimental models forming part of behavioural, surgical studies, etc. Phenotypic selection of reproducers for stabling.
*Morphological phenotyping.
2.CIBERER database: models available, genic expression and phenotype.
3. Technical-scientific advice.
4. Training

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Phenotype data for single-gene knockouts



The IMPC offers a wide range of free, open-access resources for all our users. Our phenotype data is available in the following formats:

Gene and Phenotype pages: All data from our phenotyping centres is QCd (Quality Controlled), analysed and processed to be displayed to anyone with an internet connection, for free! You can also order IMPC Alleles supplied by our consortium members in the Order Mice section. Enter a gene symbol or phenotype to start your search.
Bulk Data: For users and collaborators that want to use our data in their own custom queries we offer FTP, API and Batch Query access to our data for all your analysis needs!
Advanced Tools: We have built a variety of advanced tools to help view, use and analyse our data.
Data Collections: We have curated pages that highlight certain areas of our data that are key to a number of research areas. Examples include cardiovascular, embryo development and pain.

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