Models & Tools

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high containment research services

Provided by EUROPEAN RESEARCH INFRASTRUCTURE ON HIGHLY PATHOGENIC AGENTS (ERINHA)

Erinha

The services offered by ERINHA includea.o.
• Access to state of art European high containment (BSL4 & BSL3) and complementary facilities to advance research on high-consequence pathogens. In-vivo testing with a variety of animal models (including small rodents, ferrets, and non-human primates). In-vitro experiments using highly pathogenic agents with both in-person and remote access possibilities.

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preclinical platforms

Provided by GENETHON

Genethon

Genethon has platforms available which are capable of generating and collecting all the preclinical data which make it possible to evaluate efficacy, toxicity and adverse effects of a gene therapy product, including functional exploration, imaging, histology, cytology as well as an animal experimentation center

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 Bioinformatics service 

Provided by IFB - FRENCH INSTITUTE OF BIOINFORMATICS

france bioinformatique

The IFB’s services have two main objectives: the deployment of a high-performance bioinformatics service optimized for the needs of the life sciences communities (university laboratories and industries) and the development of innovative bioinformatics resources to address strategic challenges in health, environment and agriculture. As such, IFB provides support, account opening, software and database installation, website and virtual machine hosting, software/database/ information system development and bio-data analysis

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Mouse models

Provided by PHENOMIN

Phenomin provides access to more than 50 mouse rare disease models. These models are useful for decrypting the mechanisms behind of the specific disease and form a platform for testing therapies

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 Mouse Models

Provided by INFRAFRONTIER

infrafrontier

Services offered by INFRAFRONTIER include
• Rodent Model Generation (generation of custom rodent mutant strains using the latest genome-editing technologies by expert laboratories)
• Cryopreservation (Mutant mouse models generated by researchers around the world are archived using the latest cryopreservation techniques in the European Mouse Mutant Archive (EMMA).
• Strain Distribution (The deposited mutant mouse lines are sent to researchers around the globe as frozen gametes or live cohorts.
• Mouse Phenotyping (These systematic phenotyping platforms incorporate whole-system screen covering different diseases and organ systems.
• Axenic Service (This service offers the germ-free derivation of user-provided mouse strains. These germ-free mice can be used for different gnotobiotic studies that shed light on the important contribution of the gut microbiota to health disease).
• Open Calls (free-of-charge cancer and infectious disease services funded by the European Commission).
• Cancer Services (Via the canSERV project, INFRAFRONTIER offers access to several cutting-edge cancer services as Trans-National Access calls).

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Bioinformatic tools

Provided by RD CONNECT

RD Connect

RD-Connect has developed several bioinformatic tools to help researchers analyse omics data and identify targets for potential therapies. These include variant analysis and annotation tools as well as therapeutic prediction tools and gene-drug interaction resources, many of which are integrated in the Genome-Phenome Analysis Platform. RD-Connect Genome-Phenome Analysis Platform is a userfriendly tool that lets researchers and clinicians analyse DNA sequencing data and link them to clinical information (i.e. description of symptoms of the patients). This helps to understand how genes determine the disease symptoms and their severity, make accurate genetic diagnosis and design better treatment.

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Phenotyping of Laboratory Animals

Provided by SEFALER: LABORATORY ANIMALS PHENOTYPING NETWORK

The SEFALer platform is a pioneering network structure seeking to provide a comprehensive service in all phases of phenotyping animal models of rare diseases. It is structured through cooperation between services provided by CIBERER groups through different institutions.Actvities include:
1. Characterisation of animal models of human rare diseases.
*Secondary functional phenotyping in the following contexts:
– Platforms for phenotyping transgenic mice.
– Pharmacology and toxicology.
– Degeneration and regeneration studies.
– Ageing studies.
– Characterisation of experimental models forming part of behavioural, surgical studies, etc. Phenotypic selection of reproducers for stabling.
*Morphological phenotyping.
2.CIBERER database: models available, genic expression and phenotype.
3. Technical-scientific advice.
4. Training

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Software Tools Platform to access, analyse and integrate biological data

Provided by ELIXIR

The Tools Platform helps communities find, register and benchmark software tools. These tools help researchers access, analyse and integrate biological data, and so drive scientific discovery across the life sciences.
We maintain information standards for these tools, and produce, adopt and promote best practices for their development. We also:
*connect tools and data services
*link tools to training materials
*make it easy to download, deploy, and benchmark tools for performance
*put tools in the context of the common workflows in bioinformatics, including container technologies and Galaxy.

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Phenotype data for single-gene knockouts

Provided by INTERNATIONAL MOUSE PHENOTYPE CONSORTIUM (IMPC)

IMPC

The IMPC offers a wide range of free, open-access resources for all our users. Our phenotype data is available in the following formats:

Gene and Phenotype pages: All data from our phenotyping centres is QCd (Quality Controlled), analysed and processed to be displayed to anyone with an internet connection, for free! You can also order IMPC Alleles supplied by our consortium members in the Order Mice section. Enter a gene symbol or phenotype to start your search.
Bulk Data: For users and collaborators that want to use our data in their own custom queries we offer FTP, API and Batch Query access to our data for all your analysis needs!
Advanced Tools: We have built a variety of advanced tools to help view, use and analyse our data.
Data Collections: We have curated pages that highlight certain areas of our data that are key to a number of research areas. Examples include cardiovascular, embryo development and pain.

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Computational Services

Provided by INSTRUCT-ERIC

instruct-eric

Services offered by Instruct include
Computational Services for Structural Biology: Bioinformatics Tools, Integrative Modelling, Crystallography, Electron Microscopy, NMR
More information about our current technology offering can be found at https://instruct-eric.eu/platform-catalogue

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