ESGI provides access to new genomic technologies and analytic tools, including
* DNA analysis
* Long Read analysis
* Transcriptome Analysis
*3D genomics
*single cell analysis
*Epigenomic Analysis
Germany
Genomics and Proteomics core facility
Provided by GERMAN CANCER RESEARCH CENTER GENOMICS & PROTEOMICS CORE FACILITY
Genomics and Proteomics Core Facility has integrated Many different services:
The Microarray Unit performs expression profiling of mRNA and miRNA, Genotyping and genome-wide methylation analysis.
High-Throughput sequencing is offered and monoclonal antibodies, stable isogenic recombinant cell lines and a clone and vector repository are available.
Additionally we provide booking of central GPCF equipment like Real Time PCR machines, sample preparation robots or SilverQuant scanning systems or the wetlab wiki, which allows you to share and discuss protocols with your colleagues at DKFZ.
Services offered by INFRAFRONTIER include
• Rodent Model Generation (generation of custom rodent mutant strains using the latest genome-editing technologies by expert laboratories)
• Cryopreservation (Mutant mouse models generated by researchers around the world are archived using the latest cryopreservation techniques in the European Mouse Mutant Archive (EMMA).
• Strain Distribution (The deposited mutant mouse lines are sent to researchers around the globe as frozen gametes or live cohorts.
• Mouse Phenotyping (These systematic phenotyping platforms incorporate whole-system screen covering different diseases and organ systems.
• Axenic Service (This service offers the germ-free derivation of user-provided mouse strains. These germ-free mice can be used for different gnotobiotic studies that shed light on the important contribution of the gut microbiota to health disease).
• Open Calls (free-of-charge cancer and infectious disease services funded by the European Commission).
• Cancer Services (Via the canSERV project, INFRAFRONTIER offers access to several cutting-edge cancer services as Trans-National Access calls).
The INFRAFRONTIER Research Infrastructure and its partners offer a wide range of state-of-the-art training opportunities: Mouse clinics in different European countries provide outstanding trainings in first-line mouse phenotyping as well as specialised phenotyping courses covering e.g. mouse osteology and mouse blood and lymphatic vessel phenotyping.
The INFRAFRONTIER courses cover unique training opportunities in mouse model development as well as hands on cryopreservation courses offered by EMMA partners for many years.
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The center offers high-throughput sequencing services on the latest Illumina Next Generation Sequencer NovaSeq6000, Oxford Nanopore Technologies Sequencer PromethION and Pacific Bioscience Sequel.
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Centralized Next Generation Sequencing (NGS) services are complemented with existing decentralized NGS and bioinformatics expertise of the WGGC partners. Such expertise covers most aspects of NGS research, encompassing capabilities in human and medical genetics as well as onco and plant genomics.
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Guidelines and advice for professionals and patients
Best Practice Guidelines on molecular diagnostics in Duchenne / Becker muscular dystrophies (2010)
Diagnosis and management of Duchenne muscular dystrophy
Consensus statement for standard of care in spinal muscular atrophy (2007)
Heart failure DEGAM guideline No. 9 (2006)
Diagnostics and therapeutic approaches for mitochondrial disease in children and adolescents – S2 guideline (2009)
Diagnosis of myopathies (2008)
Guidelines for the molecular genetic diagnosis of muscular dystrophies Duchenne and Becker (1999)
Consensus statement on standard of care for congenital muscular dystrophies (2010)
Global registry for human pluripotent stem cell lines
Provided by Human Pluripotent Stem Cell Registry (hPSCreg)
Benefits of the global registry for human pluripotent stem cell lines hPSCreg are
– increased visibility of your hPSC line within the regenerative medicine community worldwide
– assignment of a unique cell line reference code to allow traceability in published papers and across federated on-line resources
– obtain hPSC certificates to fulfill ethical provenance requirements for EC-funded research projects
– recognition of source biomaterial ethical provenance and other cell line characteristics
Scientific Services available from DSMZ:
– Services Microorganisms:
Biochemical Analyses
Bioinformatic Services
Microbiological Analyses
Reference Material for Research Purposes
– Services Human and Animal Cell Lines:
Animal Cell Line Species Testing
Authentication of Human Cell Lines
Mycoplasma Detection
Mycoplasma Elimination
Online STR Analysis
Virus Testing
– Services Plant Viruses:
Plant Virus Diagnosis
Plant Virus Disease Clinic
Mouse cell lines repository
Provided by The EuMMCR (European Mouse Mutant cell Repository) from Helmholtz Zentrum München
The EuMMCR (European Mouse Mutant cell Repository) is the mouse ES cell distribution unit in Europe. The EuMMCR has been founded as distribution unit of EUCOMM (European Mouse Mutagenesis Program) and is located at the Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH in Munich, Germany. The EuMMCR unit distributes targeting vectors and mutant ES cell lines produced in the EUCOMM and EUCOMMTOOLS consortia.
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