The CCAC guidelines: Nonhuman primates provides information for investigators, animal care committees, facility managers, veterinarians and animal care staff to help facilitate improvement in both the care given to nonhuman primates and the manner in which experimental procedures are carried out
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NC3Rs Guidelines: Non-human primate, accommodation, care and use
Published by National Centre for the ReplacementRefinement and Reduction of Animals in Research
NHPNonhuman primatesThis Guideline is created by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) which supports the principles
of the 3Rs and provides the high standards of accommodation and care for animals used in research.
A guide for the laboratory use of zebrafish Danio (Brachydanio) rerio
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Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice
Published by Neuromuscular Disorders
TREAT-NMDMiceNeuromuscular diseasesThe authors propose the introduction of a standard study design for the mdx mouse model. Several aspects, including animal care, sampling times and choice of tissues, as well as recommended endpoints and methodologies are addressed and, for each aspect, a standard procedure is proposed. Testing of all new molecules/drugs using a widely accepted and agreed upon standard experimental protocol would greatly improve the power of pre-clinical experimentations and help identifying promising therapies for the translation into clinical trials for boys with Duchenne Muscular Dystrophy
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Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT)
Published by The Company of Biologists Ltd
TREAT-NMDNeuromuscular diseasesMouse modelsThis Review evaluates the experience accumulated by the TREAT-NMD Advisory Committee for Therapeutics, which provides detailed constructive feedback on clinical proposals for neuromuscular diseases. It emphasizes that a timely critical review of preclinical efficacy data from animal models, including biomarkers for specific diseases, combined with adherence to existing guidelines and standard protocols, can significantly help to de-risk clinical programs and prevent disappointments and costly engagement.
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Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?
Published by JACC: Basic to Translational Science
Animal ModelsClinical TrialToxicityThis review discusses issues in using animals to predict human toxicity in pharmaceutical development. Part 1 focuses on scientific concerns over the validity of animal research
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Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Part 2: Potential Alternatives to the Use of Animals in Preclinical Trials
Published by JACC: Basic to Translational Science
ToxicityAnimal ModelsAlternatives to the Use of AnimalsClinical TrialThis second part of the series focuses on some alternatives to animal trials as well as current regulatory discussions and developments regarding such alternatives.
View this resource Bookmark this resourceThe Zebrafish Information Network (ZFIN) is the database of genetic and genomic data for the zebrafish (Danio rerio) as a model organism. ZFIN provides a wide array of expertly curated, organized and cross-referenced zebrafish research data.
View this resource Bookmark this resourceOpen access research journal on Drosophila developmental/evolutionary biology, organogenesis, neurobiology, circadian rhythms, learning & memory, sex determination & speciation.
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