This toolkit aims to provide a guide for researchers, charities and others embarking on repurposing projects. It highlights common activities, issues and considerations at each development stage and signpost to other available resources. The content is mostly styled as questions – what should I be considering at each development stage? It is intended to stimulate thinking and not as a step-by-step guide, which reflects the variable nature of repurposing.
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EATRIS Regulatory support
Published by n/a
Orphan Drug DesignationRegulatory SupportEATRISScientic adviceThrough a combination of in-house and external partnerships with a range of regulatory experts and groups, EATRIS can provide regulatory support for most types of product including: Expert opinion, Orphan Drug Designation and Scientific Advice application at the EMA, Pre-clinical and clinical plan development, Informal scientific advice with selected national competent authorities, for highly complex projects,
access to EATRIS Regulatory Database (free of charge) that contains information about the regulatory requirements, guidelines and legislations from 27 EU countries (as well as Norway, Switzerland, Turkey and Israel) regarding drug and medical device development derived from the application of European legislation.
Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start- up Companies
Published by EATRIS
Research and Drug DevelopmentDrug Discovery GuidelineSmall MoleculeDrug RepurposingTarget Validation Drug DevelopmentNCATSNIHThis manual contains guidelines to develop therapeutic hypotheses, target and pathway validation, proof of concept criteria and generalized cost analyses at various stages of early drug discovery. Various decision points in developing a New Chemical Entity (NCE), description of the exploratory Investigational New Drug (IND) and orphan drug designation, Drug Repurposing and drug delivery technologies are also described and geared toward those who intend to develop new drug discovery and development programs.
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Exploring the new horizons of Drug Repurposing: A vital tool for turning hard work into smart work
Published by European Journal of Medicinal Chemistry
Research and Drug DevelopmentClinical TrialDrug DiscoveryDrug RepurposingLead MoleculeThis review provides different approaches for Drug Repurposing and addresses recent developments and future scope of drug repositioning strategies. In addition provides a list of repurposed drugs and repurposing resources.
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Challenges and opportunities with Drug Repurposing: finding strategies to find alternative uses of therapeutics
Published by Expert Opinion on Drug Discovery
Research and Drug DevelopmentIntellectual PropertyDrug DiscoveryDrug RepurposingBig DataRare DiseaseNeglected DiseaseCrowdfundingPrecision MedicineArticle that cover the most significant challenges and opportunities in Drug Repurposing.
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Drug Repurposing: progress, challenges and recommendations
Published by Nature Reviews Drug Discovery
Research and Drug DevelopmentDrug DiscoveryDrug RepurposingIn this Article, it is presented approaches used for Drug Repurposing (also known as drug repositioning), discussed the challenges faced by the repurposing community and recommended innovative ways by which these challenges could be addressed to help realize the full potential of Drug Repurposing.
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Drug repositioning: a brief overview
Published by
Research and Drug DevelopmentDrug DiscoveryDrug RepurposingGenericOverview of the drug repositioning benefits both its public health benefits and its commercial value.
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Discovering New Therapeutics Uses for Existing Molecules (NTU) program, National Center for Advancing Translational Sciences (NCATS)
Published by IRDiRC
Orphan DrugDrug RepurposingNCATSResearch and Drug DiscoveryNTU-NCATSFundingThe NTU program aims to improve the process of developing new treatments for diseases by finding new uses for existing therapies that already have cleared several key steps along the development path. Existing or partially developed therapeutic candidates can be repurposed for use in new disease indications
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Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses)
Published by NCATS
RepurposingThe New Therapeutic Uses program aims to improve the process of developing new treatments and cures for disease by finding new uses for assets that already have cleared several key steps along the development path (also known as Drug Repurposing).
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Review of Drug Repositioning Approaches and Resources
Published by Int J Biol Sci.
Drug RepurposingComputational ScienceIn this paper are reviewed computational approaches and highlighted their characteristics to provide references for researchers to develop more powerful approaches. At the same time, the important findings obtained using these approaches are listed
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