Small Molecules

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5 Target Deconvolution Approaches in Drug Discovery

Published by Technology Networks Drug Discoery

Target DeconvolutionAffinity ChromatographyExpression-CloningProtein MicroarrayCell MicroarrayBiochemical Suppression

The retrospective identification of the drug targets that underlie an observed phenotypic response is termed Target Deconvolution. Target Deconvolution can be achieved by numerous methods including; Affinity Chromatography, Expression-Cloning, Protein Microarray, ‘reverse transfected’ Cell Microarray, and Biochemical Suppression

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A Specialized Platform for Innovative Research Exploration (ASPIRE)

Published by NCATS

ASPIRESmall MoleculeReproducibility

By addressing long-standing challenges in the field of chemistry, including lack of standardization, low Reproducibility and an inability to predict how new chemicals will behave, ASPIRE is designed to bring novel, safe and effective treatments to more patients more quickly at lower cost.

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PudChem

Published by NIH

Small MoleculePatentToxicologyPudChemChemical StructureSafety

PubChem is an open chemistry database at the National Institutes of Health (NIH). PubChem mostly contains Small Molecules, but also larger molecules such as nucleotides, carbohydrates, lipids, peptides, and chemically-modified macromolecules.It collects information on Chemical Structures, identifiers, chemical and physical properties, biological activities, patents, health, Safety, toxicity data, and many others

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3-D Tissue Bioprinting program

Published by NCATS

Organoid3-D Tissue Model

The goal of the NCATS 3-D Tissue Bioprinting program is to advance the process of discovery and development of new medicines by developing new assay models that better predict the effects of drugs in humans. 3-D Tissue Models that mimic characteristics of live human tissues are produced on microplates to test effectiveness and toxicity of Small Molecules or other therapeutic.

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