Small Molecule

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The Assay Guidance Manual

Published by EATRIS

Small MoleculeDrug Discovery GuidelineResearch and Drug DevelopmentDrug RepurposingTarget Validation Drug DevelopmentNCATSNIH

This manual is a comprehensive resource for early drug discovery, providing guidelines for developing therapeutic hypotheses, validating targets and pathways, and establishing proof of concept criteria. It includes analyses of costs at various stages of drug development. The content encompasses critical decision-making points in New Chemical Entity (NCE) development, exploratory Investigational New Drug (IND) processes, and orphan drug designation. Furthermore, it delves into Drug Repurposing and drug delivery technologies, making it an invaluable guide for professionals initiating new drug discovery and development programs.

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Assay Development and Screening Technology (ADST)

Published by NCATS

Small MoleculeNCATSHigh Throughput Screening

One of the first steps in the drug development process is creating test systems — called assays — on which researchers assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest. At NCATS, the experts in the Assay Development and Screening Technology (ADST) program work to optimize assays requested or submitted by the biomedical research community for high-throughput small-molecule screening

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A Specialized Platform for Innovative Research Exploration (ASPIRE)

Published by NCATS

Small MoleculeReproducibilityASPIRE

By addressing long-standing challenges in the field of chemistry, including lack of standardization, low Reproducibility and an inability to predict how new chemicals will behave, ASPIRE is designed to bring novel, safe and effective treatments to more patients more quickly at lower cost.

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PudChem

Published by NIH

Small MoleculePatentToxicologyPudChemChemical StructureSafety

PubChem is an open chemistry database at the National Institutes of Health (NIH). PubChem mostly contains Small Molecules, but also larger molecules such as nucleotides, carbohydrates, lipids, peptides, and chemically-modified macromolecules.It collects information on Chemical Structures, identifiers, chemical and physical properties, biological activities, patents, health, Safety, toxicity data, and many others

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