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Core Outcome Measures in Effectiveness Trials

Provided by CORE OUTCOME MEASURES IN EFFECTIVENESS TRIALS (COMET)

Comet

COMET stands for the ‘Core Outcome Measures in Effectiveness Trials’ Initiative. It has developed a database of all studies relevant to the development of core outcome sets for use in clinical trials. The COMET initiative was set up to help in two main ways:
*to provide the COMET database as a central point where researchers, practitioners and patients can find core outcome sets that have already been developed or are still under development.
* Provide materials to support the teams who are working on core outcome sets

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DatabasE of genomiC varIation and Phenotype in Humans

Provided by DATABASE OF GENOMIC VARIATION AND PHENOTYPE IN HUMANS USING ENSEMBL RESOURCES (DECIPHER)

Decipher

DECIPHER is a clinical and research tool used by the clinical community to share and compare phenotypic and genotypic data and to
1. Aid in the interpretation of data from genome-wide analyses e.g. the differentiation between pathogenic and benign genomic variants.
2. Utilise the human reference sequence via Ensembl and other genome browsers to define which genes are involved in a specific structural variant (e.g. copy number variant) and for smaller variants (e.g. sequence variants), whether they are positioned within a gene or regulatory element and predict their likely consequence.
3. Facilitate research into the study of genes that affect human health and development to define new gene-disease and variant-disease associations and to improve diagnosis, management and therapy of rare diseases.

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Data resources and analysis tools to support life science research

Provided by EUROPEAN BIOINFORMATICS INSTITUTE (EBI)

EMBL EBI

EBI makes the world’s public biological data freely available to the scientific community via a range of services and tools and helps scientists everywhere turn information into knowledge in the following areas:
Genes, genomes & variation
Expression
Protein sequences
Molecular & cellular structures
Chemical biology
Pathways & systems

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Software Tools Platform to access, analyse and integrate biological data

Provided by ELIXIR

The Tools Platform helps communities find, register and benchmark software tools. These tools help researchers access, analyse and integrate biological data, and so drive scientific discovery across the life sciences.
We maintain information standards for these tools, and produce, adopt and promote best practices for their development. We also:
*connect tools and data services
*link tools to training materials
*make it easy to download, deploy, and benchmark tools for performance
*put tools in the context of the common workflows in bioinformatics, including container technologies and Galaxy.

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Life science Data Platform

Provided by ELIXIR

The goal of the ELIXIR Data Platform is to drive the use, re-use and value of life science data. It aims to do this by providing users with robust, long-term sustainable data resources within a coordinated, scalable and connected data ecosystem. Bioinformaticians and life science researchers in both academic and industrial settings need confidence in the sound governance, life cycle management, and long-term sustainability of those data resources.
Platform highlights
ELIXIR Core Data Resources: European data resources that are of fundamental importance to research in the life sciences and are committed to the long-term preservation of data.
ELIXIR Deposition Databases: repositories recommended for the deposition of life sciences experimental data.
Data resource services: this list is updated as Nodes finalise or review their Service Delivery Plans

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Training eSupport System (TeSS)

Provided by ELIXIR

The Training eSupport System, TeSS, is a platform that was developed to provide a one-stop shop for trainers and trainees to discover online information and content, including training materials, events and interactive tutorials. For training providers, TeSS provides opportunities to promote training events and news, and to contribute to a growing catalogue of material

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Phenotype data for single-gene knockouts

Provided by INTERNATIONAL MOUSE PHENOTYPE CONSORTIUM (IMPC)

IMPC

The IMPC offers a wide range of free, open-access resources for all our users. Our phenotype data is available in the following formats:

Gene and Phenotype pages: All data from our phenotyping centres is QCd (Quality Controlled), analysed and processed to be displayed to anyone with an internet connection, for free! You can also order IMPC Alleles supplied by our consortium members in the Order Mice section. Enter a gene symbol or phenotype to start your search.
Bulk Data: For users and collaborators that want to use our data in their own custom queries we offer FTP, API and Batch Query access to our data for all your analysis needs!
Advanced Tools: We have built a variety of advanced tools to help view, use and analyse our data.
Data Collections: We have curated pages that highlight certain areas of our data that are key to a number of research areas. Examples include cardiovascular, embryo development and pain.

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Computational Services

Provided by INSTRUCT-ERIC

instruct-eric

Services offered by Instruct include
Computational Services for Structural Biology: Bioinformatics Tools, Integrative Modelling, Crystallography, Electron Microscopy, NMR
More information about our current technology offering can be found at https://instruct-eric.eu/platform-catalogue

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Sample preparation for structural and molecular biology studie

Provided by INSTRUCT-ERIC

instruct-eric

Sample preparation is an essential prelude for structural and molecular biology studies, as well as for biotechnology and drug discovery application, which can be particularly challenging in the case of eukaryotic proteins and complexes. Instruct offer state-of-the-art infrastructures for the expression and production of biomolecules and their complexes in prokaryotic and eukaryotic systems .
Sample Preparation: Crystallisation, Nanobody Discovery, Protein Production;
Biomolecular Analysis: Imaging, Mass Spectrometry, Molecular Biophysics;
3D Structural Analysis: Electron Microscopy, Magnetic Resonance Techniques, X-ray Techniques;

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Cell culture services

Provided by The European Collection of Authenticated Cell Cultures (ECACC)

The European Collection of Authenticated Cell Cultures (ECACC) offer the following services:
– Authentication – DNA profiling and barcoding
– Bespoke cell culture services
– Cell culture training
– DNA extraction
– RNA extraction
– Human genetic services
– Mycoplasma testing
– Sterility testing

The National Collection ofType Cultures (NCTC) offer the following services:
– Freeze-drying service to customers who wish to have their own bacterial or fungal cultures preserved, with their properties maintained

Furthermore, the NCTC and ECACC offer the following additional services:
– Patent deposits: for the deposit of pathogenic bacteria, cell lines and viruses for the purposes of patenting under the Budapest Treaty.
– Safe deposits: for secure, confidential, secondary storage facility for your valuable microbial and viral seed stocks or cell bank

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