EPTRI centralised services

Provided by EPTRI

EPTRI

The EPTRI centralised services are provided by experts involved in the EPTRI Central Hub:
1. Paediatric ELSI (Ethical-Legal-Societal Issues) Advice
2. Advice on the design and requirements of not clinical specific studies/experiments
3. Advice on regulatory issues
4. Advice on translation into clinical phases

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EPTRI integrated services

Provided by EPTRI

EPTRI

EPTRI provides integrated services for research developments through its five Thematic Research Platforms according to their specific research area of expertise:
1. PAEDIATRIC MEDICINES DISCOVERY, which relates to the early-stage discovery and development of druggable molecular targets specific to paediatric disease, as well as discovery of new drugs specific for the paediatric population.
2. PAEDIATRIC BIOMARKERS, performing research to identify, characterise and validate new biomarkers for diagnosis, prognosis and personalised therapy in paediatric diseases; provide access to/deposit of annotated paediatric biological samples.
3. DEVELOPMENTAL PHARMACOLOGY, concerning studies on the pharmacological characteristics of drugs and related body response, based on the knowledge of growth and development/maturation of the organs and functions
4. PAEDIATRIC MEDICINES FORMULATIONS, which develops appropriate age-specific formulations and adequate delivery systems for preterm neonates, infants, toddlers, children and adolescents.
5. PAEDIATRIC MEDICAL DEVICES to cover the gap in medical devices tailored for children addressing the changes in growth and psychosocial maturation, physiology, and pathophysiology, and avoid inappropriate repurposing of adult technologies.

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Metabolomics facility

Provided by SYSBIO – Centre of Systems Biology

SYSBIO

METABOLOMICS FACILITY (Free or charged)
With the Metabolomics facility you can explore the metabolic profiles of your samples, identify the most interesting variation between conditions, and see the metabolic flux in action. The Metabolomics Facility includes:
*A complete metabolomics platform (GC-QTOF, LC-QTOF, and specific software)
*Seahorse XF24 Analyzer
*YSI 2950D Biochemistry Analyzer
Each instrument is available for specific and diverse analyses, from deep metabolomics analysis to simpler indication about the most important metabolic species (e.g. lactate, oxygen, glutamine, etc.).

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COSYS – open computational platform for Systems Biology

Provided by SYSBIO – Centre of Systems Biology

SYSBIO

COSYS is an open computational platform designed for the Systems Biology community. Designed to help life scientists to easily access basilar systems biology tools, it can be also used with effectiveness by skilled systems biologists. Cooperation-driven and user-friendly, COSYS is a unified tool for biological modeling (mechanistic and constraint-based), simulation and analysis, providing users with the cutting edge of GPU-powered computation. COSYS is free of charge, and can be used by everyone.

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M4 – Make Me My Model- Flux Balance Analysis

Provided by SYSBIO – Centre of Systems Biology

SYSBIO

M4 – MAKE ME MY MODEL consultancy service – Flux Balance Analysis
M4 – Make Me My Model is an initiative of ISBE light, the starting pilot of ISBE. At SYSBIO, you can contact us to develop a metabolic math model specific for your research. This constraint-based model approach, called Flux Balance Analysis, could be of great usefulness to understand your data and improve the impact of your publication (i.e. better journal, wider and multidisciplinary approach, etc.). Different approaches can be provided, thanks to ISBE partners.

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Services for research, clinical trials and technology transfer

Provided by CIDSTEM - INTERDEPARTMENTAL CENTRE FOR STEM CELLS AND REGENERATIVE MEDICINE

unimore

CIDSTEM has a GMP-authorized facility for the implementation of advanced therapies and the technical and professional skills to manage the GMP laboratory and clinical trials of these therapies.
It therefore possesses the know-how and instrumentation necessary to offer companies:
-an implementation service for research and clinical trials, approved by regulatory bodies, of advanced therapies involving cell cultures in GMP;
-A consulting service for the technological transfer of clinical and preclinical trials in GMP and for the production of cell cultures for advanced therapies.
-An implementation service of research aimed at the industrialization of cell cultures for the development of ATMPs;
-a testing service of new technologies (nanomaterials, scaffolds for the realization of 3D cellular tissues, laboratory equipment, software for clinical trials and for the management of biological data, GMP compliant logistics, etc.).

Translated with www.DeepL.com/Translator (free version)

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European Rare Disease Registry Infrastructure

Provided by EUROPEAN PLATFORM ON RARE DISEASE REGISTRATION (EU RD PLATFORM)

EC

The European Rare Disease Registry Infrastructure (ERDRI) renders rare disease registries’ data searchable and findable. This is achieved through the provision of following components: European Directory of Registries (ERDRI.dor), Central Metadata Repository (ERDRI.mdr) and Pseudonymisation Tool.

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