An appropriate disease model is an animal, cellular or (3D) organoid displaying all or some of the pathological processes that are observed in the actual human or animal disease. Studying disease models aids understanding of how the disease develops and in testing potential therapeutic treatments or interventions. No model is perfect; it is thus very important to work with relevant experts to understand the benefits and limitations of a given model (e.g. for an individual patient vs entire population), to choose the most predictable read-out (incl. biomarkers) and select the best combination of studies and models for robust validation of the working hypothesis. Thus, the right disease model is validated and correlates well with clinical observations.