The Leiden Open (source) Variation Database (LOVD) provides a flexible, freely available tool for genomic variant and phenotype collection, display and curation. LOVD allows both patient-centered and gene-centered views. LOVD is used to diagnose and advise patients carrying a genetic disease. Ideally, if a patient has been screened for mutations and one has been found, information in LOVD can predict the progress of the disease. LOVD is open source, released under the GPL license, and is actively being improved. On the server in Leiden, LOVD offers free hosting and support of LOVD-powered gene variant databases. To maintain a high quality of the data stored, LOVD connects with various resources, like HGNC, NCBI, EBI and Mutalyzer.
The toolbox has been developed through funding from the EJP RD project.
The European Joint Programme on Rare Diseases is an initiative that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement N°825575
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